Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
USERS' SCORE
Moderately Good
Based on 33 Reviews
7.9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Nattokinase (2,000 FU) (enzyme from Natto Extract) (Non-GMO soy derived)
100 mg
**
Top Medical Research Studies
0
We examined how nattokinase affects the progression of atherosclerosis and related biomarkers in a double-blind trial involving 265 participants averaging 65 years old, who had no cardiovascular disease. Participants received either nattokinase or a placebo for three years.
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
Read More
8
We explored how nattokinase (NK), a strong clot-buster, can be delivered effectively using NK-conjugated magnetite nanoparticles (NK-MNPs). These nanoparticles were designed to release NK directly at the site of a thrombus and showed promising results in sustained release and thrombolytic potential.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
Read More
9.5
We explored an innovative approach to treating blood clots using specially designed magnetic nanorobots that deliver nattokinase directly to targeted areas. These tiny robots are not only able to navigate through blood vessels but also use a combination of magnetic fields to break down clots effectively.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
Read More
Most Useful Reviews
9
Supports heart health
30 people found this helpful
Nattokinase, derived from fermented soy, has shown promise in clinical studies for promoting heart and circulatory health. It dissolves excess fibrin in blood vessels, improves circulation, and reduces the risk of severe thrombus formation. Additionally, it lowers bad LDL cholesterol and encourages good HDL cholesterol, reduces blood viscosity, and lowers blood pressure. I’ve been taking it consistently for over four months, and it has helped significantly, especially among those over 55 who often suffer from cardiovascular diseases.
Read More
9
Improves circulation
14 people found this helpful
Nattokinase is an excellent blood thinner with no reported side effects. It truly aids in reducing fibrin and optimising blood circulation. My daughter, who suffers from Lyme disease and had hypercoagulated blood, has benefitted immensely from this product. Her herbal treatments are now more effective, allowing her to regain substantial health. I am extremely grateful to iHerb for offering such a valuable product at an affordable price!
Read More
7.5
Helps prevent heart disease
3 people found this helpful
Studies indicate that nattokinase dissolves blood clots, promoting good blood vessel structure, enhancing blood flow, and lowering heart disease risk. It reduces blood pressure, easing strain on the heart that could lead to attacks. The capsules are small and easy to swallow.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
- All Researches
9.5
We explored an innovative approach to treating blood clots using specially designed magnetic nanorobots that deliver nattokinase directly to targeted areas. These tiny robots are not only able to navigate through blood vessels but also use a combination of magnetic fields to break down clots effectively.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
Read More
8
We examined how a new treatment combining nattokinase with manganese oxide nanozymes might help with acute myocardial infarction, a serious heart condition often caused by blood clots.
Our study revealed that administering this innovative combination through injection significantly improved blood vessel function and decreased heart damage in mice.
The results suggest that these nattokinase-loaded nanozymes could offer a promising strategy to tackle heart attacks effectively, particularly through their antioxidant and thrombolytic properties.
Our study revealed that administering this innovative combination through injection significantly improved blood vessel function and decreased heart damage in mice.
The results suggest that these nattokinase-loaded nanozymes could offer a promising strategy to tackle heart attacks effectively, particularly through their antioxidant and thrombolytic properties.
Read More
8
We explored the effectiveness of a specific strain of Bacillus subtilis in producing nattokinase to enhance fermented milk's health benefits. This probiotic contributed to significant thrombolytic activity, which helps prevent blood clots, a major factor in cardiovascular disease.
Our study demonstrated that fermented milk from B. subtilis could inhibit thrombosis in mice, indicating a promising way to integrate healthy options in our diets. Notably, sensory evaluations revealed that this functional fermented milk was well-accepted, similar to traditional options.
Overall, our findings highlight the potential of B. subtilis JNFE0126-fermented milk as a delicious, healthful alternative that may help reduce cardiovascular risks.
Our study demonstrated that fermented milk from B. subtilis could inhibit thrombosis in mice, indicating a promising way to integrate healthy options in our diets. Notably, sensory evaluations revealed that this functional fermented milk was well-accepted, similar to traditional options.
Overall, our findings highlight the potential of B. subtilis JNFE0126-fermented milk as a delicious, healthful alternative that may help reduce cardiovascular risks.
Read More
8
We explored how nattokinase (NK), a strong clot-buster, can be delivered effectively using NK-conjugated magnetite nanoparticles (NK-MNPs). These nanoparticles were designed to release NK directly at the site of a thrombus and showed promising results in sustained release and thrombolytic potential.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
Read More
8
Nattokinase-enhanced nanocomposites for thrombolysis
We explored the potential of nattokinase, a promising thrombolytic agent, by creating stable nanocomposites using polylysine dendrimers. Through innovative methods, we ensured that nattokinase was effectively protected from environmental factors, enhancing its stability and activity.
When combined at a 1:30 molar ratio, these nanocomposites demonstrated a remarkable thrombolysis rate, effectively targeting blood clots while minimizing risk of complications. This research indicates that these nanostructures could pave the way for safer and more effective thrombolytic therapies.
When combined at a 1:30 molar ratio, these nanocomposites demonstrated a remarkable thrombolysis rate, effectively targeting blood clots while minimizing risk of complications. This research indicates that these nanostructures could pave the way for safer and more effective thrombolytic therapies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 33 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports heart health
30 people found this helpful
Nattokinase, derived from fermented soy, has shown promise in clinical studies for promoting heart and circulatory health. It dissolves excess fibrin in blood vessels, improves circulation, and reduces the risk of severe thrombus formation. Additionally, it lowers bad LDL cholesterol and encourages good HDL cholesterol, reduces blood viscosity, and lowers blood pressure. I’ve been taking it consistently for over four months, and it has helped significantly, especially among those over 55 who often suffer from cardiovascular diseases.
Read More
9
Improves circulation
14 people found this helpful
Nattokinase is an excellent blood thinner with no reported side effects. It truly aids in reducing fibrin and optimising blood circulation. My daughter, who suffers from Lyme disease and had hypercoagulated blood, has benefitted immensely from this product. Her herbal treatments are now more effective, allowing her to regain substantial health. I am extremely grateful to iHerb for offering such a valuable product at an affordable price!
Read More
7.5
Helps prevent heart disease
3 people found this helpful
Studies indicate that nattokinase dissolves blood clots, promoting good blood vessel structure, enhancing blood flow, and lowering heart disease risk. It reduces blood pressure, easing strain on the heart that could lead to attacks. The capsules are small and easy to swallow.
Read More
9
Maintains heart health
2 people found this helpful
According to WebMD, Nattokinase dissolves blood clots, maintaining blood vessel structure, improving flow, and lowering heart disease risks. It may also help reduce blood pressure, easing the strain on the heart, which can lead to heart attacks. Numerous doctors echo this sentiment, and I am grateful iHerb offers this essential nutrient.
Read More
9
Improved blood flow
2 people found this helpful
This site offers a great selection of natural products! I gave Nattokinase to my father, who suffers from asymptomatic coronary heart disease, to enhance his blood flow. His tests and blood colour indicate that it's effective!
Read More
Frequently Asked Questions
9
Supports heart health
30 people found this helpful
Nattokinase, derived from fermented soy, has shown promise in clinical studies for promoting heart and circulatory health. It dissolves excess fibrin in blood vessels, improves circulation, and reduces the risk of severe thrombus formation. Additionally, it lowers bad LDL cholesterol and encourages good HDL cholesterol, reduces blood viscosity, and lowers blood pressure. I’ve been taking it consistently for over four months, and it has helped significantly, especially among those over 55 who often suffer from cardiovascular diseases.
7.5
Supports heart health
1 people found this helpful
I purchase Nattokinase regularly. After a relative suffered a heart attack, my cardiovascular system needed support. With the supplements, my heart dyspnea has improved significantly after six months.
9
Improves blood circulation
1 people found this helpful
An excellent choice for those concerned about their blood vessels! After starting Nattokinase for cardiovascular support, I was pleasantly surprised by its effects. My circulation improved, I felt lighter, and my blood pressure stabilised.
9
Eases numbness
1 people found this helpful
Excellent! This is the second time I've bought this product. After experiencing a TIA and thick blood, I’ve noticed considerable reduction in neck numbness since using Nattokinase. Although there’s still slight numbness in my tongue, it has significantly improved. I plan to keep using this supplement.
7.5
Decreased heart symptoms
2 people found this helpful
I take Nattokinase due to elevated red blood cells and impaired heart function after COVID-19. The heart symptoms have significantly decreased. I highly recommend it to anyone avoiding chemicals when possible. It's an excellent blood thinner, and I plan to have my blood levels checked next month.
9
Improved blood flow
2 people found this helpful
This site offers a great selection of natural products! I gave Nattokinase to my father, who suffers from asymptomatic coronary heart disease, to enhance his blood flow. His tests and blood colour indicate that it's effective!
9
Improves circulation
14 people found this helpful
Nattokinase is an excellent blood thinner with no reported side effects. It truly aids in reducing fibrin and optimising blood circulation. My daughter, who suffers from Lyme disease and had hypercoagulated blood, has benefitted immensely from this product. Her herbal treatments are now more effective, allowing her to regain substantial health. I am extremely grateful to iHerb for offering such a valuable product at an affordable price!
7.5
Reduces stroke risk
11 people found this helpful
The Japanese regard natto as a superfood for blood thinning and cholesterol reduction, thus lowering the risk of cardiovascular diseases, including strokes. It is rich in vitamins B6 and E, which promote cell renewal and slow skin aging, helping individuals feel and look younger.
7.5
Lowers blood pressure
I have been purchasing antioxidant health products from this site for some time. The ingredients seem reliable, and the quality is commendable. I bought this brand of nattokinase for my family, which can lower blood pressure, protect the cardiovascular system, dilate blood vessels, and prevent blood clots. I have been taking it for over a month and am still assessing the effects.
9
Quality product choice
3 people found this helpful
Excellent product for cardiovascular health. It derives from natto, a traditional Japanese food made from fermented soybeans. It lowers the risk of stroke effectively, all without any taste. One capsule a day is sufficient as they are small.
7.5
Effective alternative therapy
1 people found this helpful
Much better than aspirin! This substance has a powerful fibrinolytic effect, absorbed into the blood, increases fluidity and affects the body's function. In modern medicine, it aids in preventing and correcting heart and blood vessel diseases. Nattokinase is a superior alternative to aspirin for maintaining normal blood density. I discovered it in Vietnam, where it's popular in Southeast Asia. I took it for my father, who uses blood-thinning medications. He took one capsule daily.
7.5
Supports cardiovascular health
2 people found this helpful
Good! Nattokinase contains 2000 Fu. Its primary function is to break down blood clots, prevent strokes caused by blood clots, and maintain cardiovascular health. Now Foods is a reputable brand, and I will continue to use it.
8
We examined how a new treatment combining nattokinase with manganese oxide nanozymes might help with acute myocardial infarction, a serious heart condition often caused by blood clots.
Our study revealed that administering this innovative combination through injection significantly improved blood vessel function and decreased heart damage in mice.
The results suggest that these nattokinase-loaded nanozymes could offer a promising strategy to tackle heart attacks effectively, particularly through their antioxidant and thrombolytic properties.
Our study revealed that administering this innovative combination through injection significantly improved blood vessel function and decreased heart damage in mice.
The results suggest that these nattokinase-loaded nanozymes could offer a promising strategy to tackle heart attacks effectively, particularly through their antioxidant and thrombolytic properties.
9.5
We explored an innovative approach to treating blood clots using specially designed magnetic nanorobots that deliver nattokinase directly to targeted areas. These tiny robots are not only able to navigate through blood vessels but also use a combination of magnetic fields to break down clots effectively.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
0
We examined how nattokinase affects the progression of atherosclerosis and related biomarkers in a double-blind trial involving 265 participants averaging 65 years old, who had no cardiovascular disease. Participants received either nattokinase or a placebo for three years.
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
8
We investigated the effectiveness of nattokinase in managing carotid artery atherosclerosis and blood lipids over a 26-week treatment with 82 patients in two groups: one receiving nattokinase and the other statins. Both groups showed reductions in carotid plaque size and artery thickness, with the nattokinase group experiencing notably larger reductions.
While both treatments improved lipid profiles, the statin group saw more significant cholesterol reductions. Notably, nattokinase increased HDL levels, showing promise as a potential alternative to statins in managing atherosclerosis, though its effects appear unrelated to lipid changes.
While both treatments improved lipid profiles, the statin group saw more significant cholesterol reductions. Notably, nattokinase increased HDL levels, showing promise as a potential alternative to statins in managing atherosclerosis, though its effects appear unrelated to lipid changes.
References
- Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763
- Gao R, Zhang W, Chen X, Shen J, Qin Y, et al. Dual Frequency-Regulated Magnetic Vortex Nanorobots Empower Nattokinase for Focalized Microvascular Thrombolysis. ACS Nano. 2024;18:29492. doi:10.1021/acsnano.4c04331
- Zhang X, Tong Y, Wang J, Lyu X, Yang R. Screening of a Bacillus subtilis strain producing both nattokinase and milk-clotting enzyme and its application in fermented milk with thrombolytic activity. J Dairy Sci. 2021;104:9437. doi:10.3168/jds.2020-19756
- Gallelli G, Di Mizio G, Palleria C, Siniscalchi A, Rubino P, et al. Data Recorded in Real Life Support the Safety of Nattokinase in Patients with Vascular Diseases. Nutrients. 2021;13. doi:10.3390/nu13062031
- Liu S, Zhu J, Liu C, Li J, Li Z, et al. Synthesis of sustained release/controlled release nanoparticles carrying nattokinase and their application in thrombolysis. Pharmazie. 2021;76:145. doi:10.1691/ph.2021.0155
- Hodis HN, Mack WJ, Meiselman HJ, Kalra V, Liebman H, et al. Nattokinase atherothrombotic prevention study: A randomized controlled trial. Clin Hemorheol Microcirc. 2021;78:339. doi:10.3233/CH-211147
- Wu H, Wang Y, Zhang Y, Xu F, Chen J, et al. Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. Redox Biol. 2020;32:101500. doi:10.1016/j.redox.2020.101500
- Pan X, Liang P, Teng L, Ren Y, Peng J, et al. Study on molecular mechanisms of nattokinase in pharmacological action based on label-free liquid chromatography-tandem mass spectrometry. Food Sci Nutr. 2019;7:3185. doi:10.1002/fsn3.1157
- Wu C, Gao C, Lü S, Xu X, Wen N, et al. Construction of polylysine dendrimer nanocomposites carrying nattokinase and their application in thrombolysis. J Biomed Mater Res A. 2018;106:440. doi:10.1002/jbm.a.36232
- Ren NN, Chen HJ, Li Y, Mcgowan GW, Lin YG. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017;97:2038. doi:10.3760/cma.j.issn.0376-2491.2017.26.005
